Clostridium difficile (C. diff) is a major source of hospital-acquired infection leading to excess morbidity, mortality and healthcare expenditure. Inappropriate testing and over-diagnosis of the infection is also a significant problem that leads to organizational overreporting of C. diff cases and diversion of needed infection prevention and quality improvement resources.

Tampa General Hospital (TGH), a 1,011-bed teaching hospital in Florida, initiated a clinical process improvement (CPI) program aimed at enhancing standardization and efficacy of treatment for conditions it identified as high priority. The goal was to develop scalable and repeatable models to tackle difficult to solve clinical initiatives and improve patient outcomes. An early priority was to decrease C. diff rates by 20%.

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